Pregnancy signs and symptoms

    • Cessation of menses: at least 10 days late
    • Breast changes:  tenderness and tingling(very early); enlargement and nodularity; nipples and areolae enlarge and deeply pigmented
    • Nausea (with or without vomiting):  morning sickness of pregnancy lasts several hours
    • Disturbances in urination: frequent urination
    • Fatigue: tiredness is one of the earliest symptoms
    • Sensation of fetal movement: fluttering or gas bubbles (quickening)
      Pregnancy
      Classification and external resources

      A pregnant woman.
      ICD-10 Z33
      ICD-9 650
      DiseasesDB 10545
      MedlinePlus 002398
      eMedicine article/259724
      MeSH D011247

      Pregnancy is the fertilization and development of one or more offspring, known as an embryo or fetus, in a woman's uterus. In a pregnancy, there can be multiple gestations, as in the case of twins or triplets. Childbirth usually occurs about 38 weeks after conception; in women who have a menstrual cycle length of four weeks, this is approximately 40 weeks from the start of the last normal menstrual period (LNMP). Human pregnancy is the most studied of all mammalian pregnancies. Conception can be achieved through sexual intercourse or assisted reproductive technology.

      An embryo is the developing offspring during the first 8 weeks following conception, and subsequently the term fetus is used until birth.[1][2] 40% of pregnancies in the United States and United Kingdom are unplanned, and between a quarter and half of those unplanned pregnancies were unwanted pregnancies.[3][4] Of those unintended pregnancies that occurred in the US, 60% of the women used birth control to some extent during the month pregnancy occurred.[5]

      In many societies' medical or legal definitions, human pregnancy is somewhat arbitrarily divided into three trimester periods, as a means to simplify reference to the different stages of prenatal development. The first trimester carries the highest risk of miscarriage (natural death of embryo or fetus). During the second trimester, the development of the fetus can be more easily monitored and diagnosed. The beginning of the third trimester often approximates the point of viability, or the ability of the fetus to survive, with or without medical help, outside of the uterus.[6]

      Terminology

      One scientific term for the state of pregnancy is gravidity (adjective "gravid"), Latin for "heavy" and a pregnant female is sometimes referred to as a gravida.[7] Similarly, the term parity (abbreviated as "para") is used for the number of times a female has given birth, counting twins and other multiple births as one pregnancy, and usually including stillbirths. Medically, a woman who has never been pregnant is referred to as a nulligravida, a woman who is (or has been only) pregnant for the first time as a primigravida,[8] and a woman in subsequent pregnancies as a multigravida or multiparous.[7][9] Hence, during a second pregnancy a woman would be described as gravida 2, para 1 and upon live delivery as gravida 2, para 2. An in-progress pregnancy, as well as abortions, miscarriages, or stillbirths account for parity values being less than the gravida number. In the case of twins, triplets etc., gravida number and parity value are increased by one only. Women who have never carried a pregnancy achieving more than 20 weeks of gestation age are referred to as nulliparous.[10]

      Progression

      Stages in prenatal development, with weeks and months numbered from last menstrual period.

      Initiation

      The initial stages of human embryogenesis.
      Fertilization and implantation in humans.

      Although pregnancy begins with implantation, the process leading to pregnancy occurs earlier as the result of the female gamete, or oocyte, merging with the male gamete, spermatozoon. In medicine, this process is referred to as fertilization; in lay terms, it is more commonly known as "conception." After the point of fertilization, the fused product of the female and male gamete is referred to as a zygote or fertilized egg. The fusion of male and female gametes usually occurs following the act of sexual intercourse, resulting in spontaneous pregnancy. However, the advent of assisted reproductive technology such as artificial insemination and in vitro fertilisation have made achieving pregnancy possible without engaging in sexual intercourse. This approach may be undertaken as a voluntary choice or due to infertility.

      The process of fertilization occurs in several steps, and the interruption of any of them can lead to failure. Through fertilization, the egg is activated to begin its developmental process, and the haploid nuclei of the two gametes come together to form the genome of a new diploid organism.

      At the beginning of the process, the sperm undergoes a series of changes, as freshly ejaculated sperm is unable or poorly able to fertilize.[11] The sperm must undergo capacitation in the female's reproductive tract over several hours, which increases its motility and destabilizes its membrane, preparing it for the acrosome reaction, the enzymatic penetration of the egg's tough membrane, the zona pellucida, which surrounds the oocyte. The sperm and the egg cell, which has been released from one of the female's two ovaries, unite in one of the two fallopian tubes. The fertilized egg, known as a zygote, then moves toward the uterus, a journey that can take up to a week to complete. Cell division begins approximately 24 to 36 hours after the male and female cells unite. Cell division continues at a rapid rate and the cells then develop into what is known as a blastocyst. The blastocyst is made up of three layers: the ectoderm (which will become the skin and nervous system), the endoderm (which will become the digestive and respiratory systems), and the mesoderm (which will become the muscle and skeletal systems). Finally, the blastocyst arrives at the uterus and attaches to the uterine wall, a process known as implantation.

      The mass of cells, now known as an embryo, begins the embryonic stage, which continues until cell differentiation is almost complete at eight weeks. Structures important to the support of the embryo develop, including the placenta and umbilical cord. During this time, cells begin to differentiate into the various body systems. The basic outlines of the organ, body, and nervous systems are established. By the end of the embryonic stage, the beginnings of features such as fingers, eyes, mouth, and ears become visible.

      Once cell differentiation is mostly complete, the embryo enters the final stage and becomes known as a fetus. The early body systems and structures that were established in the embryonic stage continue to develop. Sex organs begin to appear during the third month of gestation. The fetus continues to grow in both weight and length, although the majority of the physical growth occurs in the last weeks of pregnancy.

      Duration

      Healthcare professionals name three different dates as the start of pregnancy:

      • the first day of the woman's last normal menstrual period, and the resulting fetal age is called the gestational age
      • the date of conception (about two weeks before her next expected menstrual period), with the age called fertilization age
      • the date of implantation (about one week after conception).

      Since these are spread over a significant period of time, the duration of pregnancy necessarily depends on the date selected as the starting point chosen.

      As measured on a reference group of women with a menstrual cycle of exactly 28-days prior to pregnancy, and who had spontaneous onset of labor, the mean pregnancy length has been estimated to be 283.4 days of gestational age as timed from the first day of the last menstrual period as recalled by the mother, and 280.6 days when the gestational age was retrospectively estimated by obstetric ultrasound measurement of the fetal biparietal diameter (BPD) in the second trimester.[12] Other algorithms take into account a variety of other variables, such as whether this is the first or subsequent child (i.e., pregnant woman is a primipara or a multipara, respectively), the mother's race, parental age, length of menstrual cycle, and menstrual regularity), but these are rarely used by healthcare professionals. In order to have a standard reference point, the normal pregnancy duration is generally assumed to be 280 days (or 40 weeks) of gestational age.

      There is a standard deviation of 8–9 days surrounding due dates calculated with even the most accurate methods. This means that fewer than 5 percent of births occur on the day of being 40 weeks of gestational age; 50 percent of births are within a week of this duration, and about 80 percent are within 2 weeks.[12] It is much more useful and accurate, therefore, to consider a range of due dates, rather than one specific day, with some online due date calculators providing this information.[13]

      The most common system used among healthcare professionals is Naegele's rule, which was developed in the early 19th century. This calculates the expected due date from the first day of the last normal menstrual period (LMP or LNMP) regardless of factors known to make this inaccurate, such as a shorter or longer menstrual cycle length. Pregnancy most commonly lasts for 40 weeks according to this LNMP-based method, assuming that the woman has a predictable menstrual cycle length of close to 28 days and conceives on the 14th day of that cycle

      Accurate dating of pregnancy is important, because it is used in calculating the results of various prenatal tests, (for example, in the triple test). A decision may be made to induce labour if a fetus is perceived to be overdue. Furthermore, if LMP and ultrasound dating predict different respective due dates, with the latter being later, this might signify slowed fetal growth and therefore require closer review.

      The age of fetal viability has been receding because of continued medical progress. Whereas it used to be 28 weeks, it has been brought back to as early as 23, or even 22 weeks in some countries.[citation needed]

      Preterm, term and postterm

      Pregnancy is considered "at term" when gestation has lasted 37 complete weeks (occurring at the transition from the 37th to the 38th week of gestation), but is less than 42 weeks of gestational age (occurring at the transition from the 42nd week to the 43rd week of gestation, or between 259 and 294 days since LMP). "Full term" refers to the gestation having lasted 40 weeks from the first day of the mother's last menstrual period. This is the end of gestation on average. Alternatively expressed, this corresponds to a gestational age of 40 weeks and 0 days, or 280 days, or approximately 9 months, and occurs at the transition from the 40th to the 41st week of gestation. On average, it corresponds to an embryonic age of 38 weeks or 266 days.

      Events before completion of 37 weeks (259 days) are considered preterm; from week 42 (294 days) events are considered postterm.[14] When a pregnancy exceeds 42 weeks (294 days), the risk of complications for both the woman and the fetus increases significantly.[15][16] Therefore, in an otherwise uncomplicated pregnancy, obstetricians usually prefer to induce labour at some stage between 41 and 42 weeks.[17][18]

      Birth before 39 weeks by C section, even if considered "at term", results in an increases risk of complications and premature death, when not medically needed.[19] This is from factors including underdeveloped lungs, infection due to underdeveloped immune system, problems feeding due to underdeveloped brain, and jaundice from underdeveloped liver. Some hospitals in the United States have noted a significant increase in neonatal intensive care unit patients when women schedule deliveries for convenience and are taking steps to reduce induction for non-medical reasons.[20] Complications from Caesarean section are more common than for live births.

      Recent medical literature prefers the terminology preterm and postterm to premature and postmature. Preterm and postterm are unambiguously defined as above, whereas premature and postmature have historical meaning and relate more to the infant's size and state of development rather than to the stage of pregnancy.[21][22]

      Childbirth

      Childbirth is the process whereby an infant is born.

      A woman is considered to be in labour when she begins experiencing regular uterine contractions, accompanied by changes of her cervix – primarily effacement and dilation. While childbirth is widely experienced as painful, some women do report painless labours, while others find that concentrating on the birth helps to quicken labour and lessen the sensations. Most births are successful vaginal births, but sometimes complications arise and a woman may undergo a cesarean section.

      During the time immediately after birth, both the mother and the baby are hormonally cued to bond, the mother through the release of oxytocin, a hormone also released during breastfeeding. Studies show that skin-to-skin contact between a mother and her newborn immediately after birth is beneficial for both the mother and baby. A review done by the World Health Organization found that skin-to-skin contact between mothers and babies after birth reduces crying, improves mother-infant interaction, and helps mothers to breastfeed successfully. They recommend that neonates be allowed to bond with the mother during their first two hours after birth, the period that they tend to be more alert than in the following hours of early life.[23]

      Postnatal period

      The postnatal period begins immediately after the birth of a child and then extends for about six weeks. During this period, the mother's body begins the return to prepregnancy conditions that includes changes in hormone levels and uterus size.

      Diagnosis

      The beginning of pregnancy may be detected either based on symptoms by the pregnant woman herself, or by using medical tests with or without the assistance of a medical professional. Approximately 1 in 475 women at 20 weeks, and 1 in 2500 women at delivery, refuse to acknowledge that they are pregnant, which is called denial of pregnancy.[24] Some non-pregnant women have a very strong belief that they are pregnant along with some of the physical changes. This condition is known as pseudocyesis or false pregnancy.[25]

      Physical signs

      Linea nigra in a woman at 22 weeks pregnant.

      Most pregnant women experience a number of symptoms,[26] which can signify pregnancy. The symptoms can include nausea and vomiting, excessive tiredness and fatigue, cravings for certain foods that are not normally sought out, and frequent urination particularly during the night.

      A number of early medical signs are associated with pregnancy.[27][28] These signs typically appear, if at all, within the first few weeks after conception. Although not all of these signs are universally present, nor are all of them diagnostic by themselves, taken together they make a presumptive diagnosis of pregnancy. These signs include the presence of human chorionic gonadotropin (hCG) in the blood and urine, missed menstrual period, implantation bleeding that occurs at implantation of the embryo in the uterus during the third or fourth week after last menstrual period, increased basal body temperature sustained for over 2 weeks after ovulation, Chadwick's sign (darkening of the cervix, vagina, and vulva), Goodell's sign (softening of the vaginal portion of the cervix), Hegar's sign (softening of the uterus isthmus), and pigmentation of linea alba – Linea nigra, (darkening of the skin in a midline of the abdomen, caused by hyperpigmentation resulting from hormonal changes, usually appearing around the middle of pregnancy).[27][28]Breast tenderness is common during the first trimester, and is more common in women who are pregnant at a young age.[29]

      Despite all the signs, some women may not realize they are pregnant until they are far along in pregnancy. In some cases, a few have not been aware of their pregnancy until they begin labour. This can be caused by many factors, including irregular periods (quite common in teenagers), certain medications (not related to conceiving children), and obese women who disregard their weight gain. Others may be in denial of their situation.

      Tests

      Pregnancy detection can be accomplished using one or more various pregnancy tests,[30] which detect hormones generated by the newly formed placenta. Blood and urine tests can detect pregnancy 12 days after implantation.[31] Blood pregnancy tests are more sensitive than urine tests (giving fewer false negatives).[32] Home pregnancy tests are urine tests, and normally detect a pregnancy 12 to 15 days after fertilization. A quantitative blood test can determine approximately the date the embryo was conceived. Testing 48 hours apart can provide useful information regarding how the pregnancy is doing. A single test of progesterone levels can also help determine how likely a fetus will survive in those with a threatened miscarriage (bleeding in early pregnancy).[33]

      An early obstetric ultrasonography can determine the age of the pregnancy fairly accurately. In practice, medical professionals typically express the age of a pregnancy (i.e., an "age" for an embryo) in terms of "menstrual date" based on the first day of a woman's last menstrual period, as the woman reports it. Unless a woman's recent sexual activity has been limited, she has been charting her cycles, or the conception is the result of some types of fertility treatment (such as IUI or IVF), the exact date of fertilization is unknown. Without symptoms such as morning sickness, often the only visible sign of a pregnancy is an interruption of the woman's normal monthly menstruation cycle, (i.e., a "late period"). Hence, the "menstrual date" is simply a common educated estimate for the age of a fetus, which is an average of 2 weeks later than the first day of the woman's last menstrual period. The term "conception date" may sometimes be used when that date is more certain, though even medical professionals can be imprecise with their use of the two distinct terms. The due date can be calculated by using Naegele's rule. The expected date of delivery may also be calculated from sonogram measurement of the fetus. This method is slightly more accurate than methods based on LMP.[34] Additional obstetric diagnostic techniques can estimate the health and presence or absence of congenital diseases at an early stage.

      Ultrasound

      One way to observe prenatal development is via ultrasound images. Ultrasound imaging before 24 weeks can help determine the due date and detect multiple pregnancies[35] however in those who are at low risk it is unclear if this makes a significant difference in outcomes.[36] Routine ultrasound imaging after 24 weeks gestation does not improve outcomes in either the mother or the baby and might increase the risk of a cesarean section.[37] It is thus is not recommended.[36] Modern 3D ultrasound images provide greater detail for prenatal diagnosis than the older 2D ultrasound technology.[38] While 3D is popular with parents desiring a prenatal photograph as a keepsake,[39] both 2D and 3D are discouraged by the FDA for non-medical use,[40] but there are no definitive studies linking ultrasound to any adverse medical effects.[41] The following 3D ultrasound images were taken at different stages of pregnancy:

      Physiology

      Breast changes as seen during pregnancy. Note the increase in size and darkening of the areola.

      Pregnancy is typically broken into three periods, or trimesters, each of about three months.[42][43] Obstetricians define each trimester as lasting for 14 weeks, resulting in a total duration of 42 weeks, although the average duration of pregnancy is actually about 40 weeks.[44] While there are no hard and fast rules, these distinctions are useful in describing the changes that take place over time.

      First trimester

      Traditionally, medical professionals have measured pregnancy from a number of convenient points, including the day of last menstruation, ovulation, fertilization, implantation and chemical detection. In medicine, pregnancy is often defined as beginning when the developing embryo becomes implanted in the endometrial lining of a woman's uterus. Most pregnant women do not have any specific signs or symptoms of implantation, although it is not uncommon to experience minimal bleeding. After implantation, the uterine endometrium is called the decidua. The placenta, which is formed partly from the decidua and partly from outer layers of the embryo, connects the developing embryo to the uterine wall to allow nutrient uptake, waste elimination, and gas exchange via the mother's blood supply. The umbilical cord is the connecting cord from the embryo or fetus to the placenta. The developing embryo undergoes tremendous growth and changes during the process of fetal development.

      Morning sickness occurs in about seventy percent of all pregnant women, and typically improves after the first trimester.[45] Although described as "morning sickness", women can experience this nausea during afternoon, evening, and throughout the entire day.

      Shortly after conception, the nipples and areolas begin to darken due to a temporary increase in hormones.[46] This process continues throughout the pregnancy.

      The first 12 weeks of pregnancy are considered to make up the first trimester. The first two weeks from the first trimester are calculated as the first two weeks of pregnancy even though the pregnancy does not actually exist. These two weeks are the two weeks before conception and include the woman's last period.

      The third week is the week in which fertilization occurs and the 4th week is the period when implantation takes place. In the 4th week, the fecundated egg reaches the uterus and burrows into its wall which provides it with the nutrients it needs. At this point, the zygote becomes a blastocyst and the placenta starts to form. Moreover, most of the pregnancy tests may detect a pregnancy beginning with this week.

      The 5th week marks the start of the embryonic period. This is when the embryo's brain, spinal cord, heart and other organs begin to form.[47] At this point the embryo is made up of three layers, of which the top one (called the ectoderm) will give rise to the embryo's outermost layer of skin, central and peripheral nervous systems, eyes, inner ear, and many connective tissues.[47] The heart and the beginning of the circulatory system as well as the bones, muscles and kidneys are made up from the mesoderm (the middle layer). The inner layer of the embryo will serve as the starting point for the development of the lungs, intestine and bladder. This layer is referred to as the endoderm. An embryo at 5 weeks is normally between 116 and 18 inch (1.6 and 3.2 mm) in length.

      In the 6th week, the embryo will be developing basic facial features and its arms and legs start to grow. At this point, the embryo is usually no longer than 16 to 14 inch (4.2 to 6.4 mm). In the following week, the brain, face and arms and legs quickly develop. In the 8th week, the embryo starts moving and in the next 3 weeks, the embryo's toes, neck and genitals develop as well. According to the American Pregnancy Association, by the end of the first trimester, the fetus will be about 3 inches (76 mm) long and will weigh approximately 1 ounce (28 g).[48] Once pregnancy moves into the second trimester, all the risks of miscarriage and birth defects occurring drop drastically. Progesterone has noticeable effects on respiratory physiology, increasing minute ventilation by 40% in the first trimester.[49]

      Second trimester

      By the end of the second trimester, the expanding uterus has created a visible "baby bump". Although the breasts have been developing internally since the beginning of the pregnancy, most of the visible changes appear after this point.

      Weeks 13 to 28 of the pregnancy are called the second trimester. Most women feel more energized in this period, and begin to put on weight as the symptoms of morning sickness subside and eventually fade away. The uterus, the muscular organ that holds the developing fetus, can expand up to 20 times its normal size during pregnancy.

      Although the fetus begins to move and takes a recognizable human shape during the first trimester, it is not until the second trimester that movement of the fetus, often referred to as "quickening", can be felt. This typically happens in the fourth month, more specifically in the 20th to 21st week, or by the 19th week if the woman has been pregnant before. However, it is not uncommon for some women not to feel the fetus move until much later. The placenta fully functions at this time and the fetus makes insulin and urinates. The reproductive organs distinguish the fetus as male or female. During the second trimester, most women begin to wear maternity clothes.

      Third trimester

      Comparison of growth of the abdomen between 26 weeks and 40 weeks gestation.

      Final weight gain takes place, which is the most weight gain throughout the pregnancy. The fetus will be growing the most rapidly during this stage, gaining up to 28 g per day. The woman's belly will transform in shape as the belly drops due to the fetus turning in a downward position ready for birth. During the second trimester, the woman's belly would have been very upright, whereas in the third trimester it will drop down quite low, and the woman will be able to lift her belly up and down. The fetus begins to move regularly, and is felt by the woman. Fetal movement can become quite strong and be disruptive to the woman. The woman's navel will sometimes become convex, "popping" out, due to her expanding abdomen. This period of her pregnancy can be uncomfortable, causing symptoms like weak bladder control and backache. Movement of the fetus becomes stronger and more frequent and via improved brain, eye, and muscle function the fetus is prepared for ex utero viability. The woman can feel the fetus "rolling" and it may cause pain or discomfort when it is near the woman's ribs and spine.

      1858 engraving of a pregnant woman showing the fetus in the womb

      There is head engagement in the third trimester, that is, the fetal head descends into the pelvic cavity so that only a small part (or none) of it can be felt abdominally. The perenium and cervix are further flattened and the head may be felt vaginally.[50] Head engagement is known colloquially as the baby drop, and in natural medicine as the lightening because of the release of pressure on the upper abdomen and renewed ease in breathing. However, it severely reduces bladder capacity, increases pressure on the pelvic floor and the rectum, and the mother may experience the perpetual sensation that the fetus will "fall out" at any moment.[51] It is also during the third trimester that maternal activity and sleep positions may affect fetal development due to restricted blood flow. For instance, the enlarged uterus may impede blood flow by compressing the lower pressured vena cava, with the left lateral laying positions appearing to providing better oxygenation to the infant.[52]

      It is during this time that a baby born prematurely may survive. The use of modern medical intensive care technology has greatly increased the probability of premature babies surviving, and has pushed back the boundary of viability to much earlier dates than would be possible without assistance.[53] In spite of these developments, premature birth remains a major threat to the fetus, and may result in ill health in later life, even if the baby survives.

      Prenatal development

      Prenatal development is divided into two primary biological stages. The first is the embryonic stage, which lasts for about two months. At this point, the fetal stage begins. At the beginning of the fetal stage, the risk of miscarriage decreases sharply,[54] and all major structures including the head, brain, hands, feet, and other organs are present, and they continue to grow and develop. When the fetal stage commences, a fetus is typically about 30 mm (1.2 inches) in length, and the heart can be seen beating via ultrasound; the fetus can be seen making various involuntary motions at this stage.[55]

      Electrical brain activity is first detected between the 5th and 6th week of gestation, though this is still considered primitive neural activity rather than the beginning of conscious thought, something that develops much later in fetation. Synapses begin forming at 17 weeks, and at about week 28 begin to multiply at a rapid pace which continues until 3 to 4 months after birth.[56]

      Physiological changes

      Melasma pigment changes to the face due to pregnancy

      During pregnancy, the woman undergoes many physiological changes, which are entirely normal, including cardiovascular, hematologic, metabolic, renal and respiratory changes that become very important in the event of complications. The body must change its physiological and homeostatic mechanisms in pregnancy to ensure the fetus is provided for. Increases in blood sugar, breathing and cardiac output are all required. Levels of progesterone and oestrogens rise continually throughout pregnancy, suppressing the hypothalamic axis and subsequently the menstrual cycle.

      Many women and medical professionals[61][62] mistakenly think that breastfeeding causes their breasts to sag (medically referred to as ptosis),[63] and as a result some are reluctant to nurse their infants. In February 2009, Cheryl Cole told British Vogue that she hesitated to breastfeed because of the effect it might have on her breasts. "I want to breastfeed," she said, "but I've seen what it can do, so I may have to reconsider."[64] Research shows that breastfeeding is less of a factor than previously thought. The main risk factors for ptosis are cigarette smoking, a woman's body mass index (BMI), her number of pregnancies, her breast cup size before pregnancy, and age.[65][66]

      Management

      Prenatal medical care is the medical and nursing care recommended for women before and during pregnancy. The aim of good prenatal care is to identify any potential problems early, to prevent them if possible (through recommendations on adequate nutrition, exercise, vitamin intake etc.), and to manage problems, possibly by directing the woman to appropriate specialists, hospitals, etc. if necessary.

      Nutrition

      A balanced, nutritious diet is an important aspect of a healthy pregnancy. Eating a healthy diet, balancing carbohydrates, fat, and proteins, and eating a variety of fruits and vegetables, usually ensures good nutrition. Those whose diets are affected by health issues, religious requirements, or ethical beliefs may choose to consult a health professional for specific advice.

      Adequate periconceptional folic acid (also called folate or Vitamin B9) intake has been shown to decrease the risk of fetal neural tube defects such as spina bifida, a serious birth defect. The neural tube develops during the first 28 days of pregnancy, explaining the necessity to guarantee adequate periconceptional folate intake.[67][68] Folate (from folia, leaf) is abundant in spinach (fresh, frozen, or canned), and is found in green leafy vegetables e.g. salads, beets, broccoli, asparagus, citrus fruits and melons, chickpeas (i.e. in the form of hummus or falafel), and eggs. In the United States and Canada, most wheat products (flour, noodles) are fortified with folic acid.[69]

      DHA omega-3 is a major structural fatty acid in the brain and retina, and is naturally found in breast milk. It is important for the woman to consume adequate amounts of DHA during pregnancy and while nursing to support her well-being and the health of her infant. Developing infants cannot produce DHA efficiently, and must receive this vital nutrient from the woman through the placenta during pregnancy and in breast milk after birth.[70]

      Several micronutrients are important for the health of the developing fetus, especially in areas of the world where insufficient nutrition is prevalent.[71] In developed areas, such as Western Europe and the United States, certain nutrients such as Vitamin D and calcium, required for bone development, may require supplementation.[72][73][74]

      Dangerous bacteria or parasites may contaminate foods, including Listeria and Toxoplasma gondii. Careful washing of fruits and raw vegetables may remove these pathogens, as may thoroughly cooking leftovers, meat, or processed meat. Soft cheeses may contain Listeria; if milk is raw, the risk may increase. Cat feces pose a particular risk of toxoplasmosis. Pregnant women are also more prone to Salmonella infections from eggs and poultry, which should be thoroughly cooked. Practicing good hygiene in the kitchen can reduce these risks.[75]

      Weight gain

      Caloric intake should be increased to ensure proper development of the fetus. The amount of weight gained during a single pregnancy varies. The Institute of Medicine recommends an overall pregnancy weight gain for those of normal weight (body mass index of 18.5–24.9), of 11.3–15.9 kg (25–35 pounds).[76] Women who are underweight (BMI of less than 18.5), should gain between 12.7–18 kg (28–40 lbs), while those who are overweight (BMI of 25–29.9) are advised to gain between 6.8–11.3 kg (15–25 lbs) and those who are obese (BMI>30) should gain between 5–9 kg (11–20 lbs).[77]

      During pregnancy, insufficient or excessive weight gain can compromise the health of the mother and fetus. Women are encouraged to choose a healthy diet regardless of pre-pregnancy weight. Exercise during pregnancy, such as walking and swimming, is recommended for healthy pregnancies. Exercise has notable health benefits for both mother and baby, including preventing excessive weight gain.[78][79]

      Medication use

      Drugs used during pregnancy can have temporary or permanent effects on the fetus. Therefore many physicians would prefer not to prescribe for pregnant women, the major concern being over teratogenicity of the drugs.

      Drugs have been classified into categories A,B,C,D and X based on the Food and Drug Administration (FDA) rating system to provide therapeutic guidance based on potential benefits and fetal risks. Drugs, including some multivitamins, that have demonstrated no fetal risks after controlled studies in humans are classified as Category A. On the other hand drugs like thalidomide with proven fetal risks that outweigh all benefits are classified as Category X.[80]

      Exposure to toxins

      Various toxins pose a significant hazard to fetuses during development. A 2011 study found that virtually all U.S. pregnant women carry multiple chemicals, including some banned since the 1970s, in their bodies. Researchers detected polychlorinated biphenyls, organochlorine pesticides, perfluorinated compounds, phenols, polybrominated diphenyl ethers, phthalates, polycyclic aromatic hydrocarbons, perchlorate PBDEs, compounds used as flame retardants, and dichlorodiphenyltrichloroethane (DDT), a pesticide banned in the United States in 1972, in the bodies of 99 to 100 percent of the pregnant women they tested. Bisphenol A (BPA) was identified in 96 percent of the women surveyed. Several of the chemicals were at the same concentrations that have been associated with negative effects in children from other studies and it is thought that exposure to multiple chemicals can have a greater impact than exposure to only one substance.[81][medical citation needed]

      • Alcohol ingestion during pregnancy may cause fetal alcohol syndrome, a permanent and often devastating birth-defect syndrome. A number of studies have shown that light to moderate drinking during pregnancy might not pose a risk to the fetus, although no amount of alcohol during pregnancy can be guaranteed to be absolutely safe.[82]
      • Children exposed to prenatal cigarette smoke may experience a wide range of behavioral, neurological, and physical difficulties.[83]
      • Marijuna use during pregnancy is associated with deficits in language, attention, areas of cognitive performance, and delinquent behavior in offspring, through adolescence.[84]
      • Elemental mercury and methylmercury are two forms of mercury that may pose risks in pregnancy. Methylmercury, a worldwide contaminant of seafood and freshwater fish, is known to produce adverse nervous system effects, especially during brain development. Eating fish is the main source of mercury exposure in humans and some fish may contain enough mercury to harm the developing nervous system of an embryo or fetus, sometimes leading to learning disabilities.[85] Mercury is present in many types of fish, but it is mostly found in certain large fish. The United States Food and Drug Administration and the Environmental Protection Agency advise pregnant women not to eat swordfish, shark, king mackerel and tilefish and limit consumption of albacore tuna to 6 ounces or less a week.[85]
      • Air pollution can negatively affect a pregnancy resulting in higher rates of preterm births, growth restriction, and heart and lung problems in the infant.[86]
      • The developing nervous system of the fetus is particularly vulnerable to lead toxicity. Neurological toxicity is observed in children of exposed women as a result of the ability of lead to cross the placental barrier. A special concern for pregnant women is that some of the bone lead accumulation is released into the blood during pregnancy. Several studies have provided evidence that even low maternal exposures to lead produce intellectual and behavioral deficits in children.[87]

      Sexual activity

      Most women can continue to engage in sexual activity throughout pregnancy.[88] Most research suggests that during pregnancy both sexual desire and frequency of sexual relations decrease.[89][90] In context of this overall decrease in desire, some studies indicate a second-trimester increase, preceding a decrease during the third trimester.[91][92] Some individuals are sexually attracted to pregnant women (pregnancy fetishism, also known as maiesiophilia).

      Sex during pregnancy is a low-risk behavior except when the healthcare provider advises that sexual intercourse be avoided for particular medical reasons. Otherwise, for a healthy pregnant woman who is not ill or weak, there is no safe or right way to have sex during pregnancy: it is enough to apply the common sense rule that both partners avoid putting pressure on the uterus, or a partner's full weight on a pregnant belly.[93]

      Exercise

      Regular aerobic exercise during pregnancy appears to improve (or maintain) physical fitness; however, the quality of the research is poor and the data was insufficient to infer important risks or benefits for the mother or infant.[94]

      The Clinical Practice Obstetrics Committee of Canada recommends that "All women without contraindications should be encouraged to participate in aerobic and strength-conditioning exercises as part of a healthy lifestyle during their pregnancy". Although an upper level of safe exercise intensity has not been established, women who were regular exercisers before pregnancy and who have uncomplicated, healthy pregnancies should be able to engage in high intensity exercise programs, such as jogging and aerobics for less than 45 minutes, with no adverse effects if they are mindful of the possibility that they may need to increase their energy intake and are careful to not become overheated. In the absence of either medical or obstetric complications, they advise an accumulation of 30 minutes a day of exercise on most if not all days of the week. In general, participation in a wide range of recreational activities appears to be safe, with the avoidance of those with a high risk of falling such as horseback riding or sking or those that carry a risk of abdominal trauma, such as soccer or hockey.[95]

      The American College of Obstetricians and Gynecologists reports that in the past, the main concerns of exercise in pregnancy were focused on the fetus and any potential maternal benefit was thought to be offset by potential risks to the fetus. However, they write that more recent information suggests that in the uncomplicated pregnancy, fetal injuries are highly unlikely. They do, however, list several circumstances when a woman should contact her health care provider before continuing with an exercise program. Contraindications include: Vaginal bleeding, dyspnea before exertion, dizziness, headache, chest pain, muscle weakness, preterm labor, decreased fetal movement, amniotic fluid leakage, and calf pain or swelling (to rule out thrombophlebitis). [95]

      Complications

      Each year, according to the WHO, ill-health as a result of pregnancy is experienced (sometimes permanently) by more than 20 million women around the world. Furthermore, the "lives of eight million women are threatened, and more than 500,000 women are estimated to have died in 1995 as a result of causes related to pregnancy and childbirth."[96]

      Pregnancy poses varying levels of health risk for women, depending on their medical profile before pregnancy.

      The following are some of the complaints that may occur during and/or after pregnancy due to the many changes which pregnancy causes in a woman's body:

      • Pregnancy induced hypertension
      • Anemia[97]
      • Back pain. A particularly common complaint in the third trimester when the patient's center of gravity has shifted.
      • Carpal tunnel syndrome in between an estimated 21% to 62% of cases, possibly due to edema.[98]
      • Constipation. A complaint that is caused by decreased bowel mobility secondary to elevated progesterone (normal in pregnancy), which can lead to greater absorption of water.
      • Braxton Hicks contractions. Occasional, irregular, and often painless contractions that occur several times per day.
      • Edema (swelling). Common complaint in advancing pregnancy. Caused by compression of the inferior vena cava (IVC) and pelvic veins by the uterus leads to increased hydrostatic pressure in lower extremities.
      • Regurgitation, heartburn, and nausea. Common complaints that may be caused by Gastroesophageal Reflux Disease (GERD); this is determined by relaxation of the lower esophageal sphincter (LES) and increased transit time in the stomach (normal in pregnancy), as well as by increased intraabdominal pressure, caused by the enlarging uterus.
      • Haemorrhoids. Complaint that is often noted in advancing pregnancy. Caused by increased venous stasis and IVC compression leading to congestion in venous system, along with increased abdominal pressure secondary to the pregnant space-occupying uterus and constipation.
      • Pelvic girdle pain. PGP disorder is complex and multi-factorial and likely to be represented by a series of sub-groups with different underlying pain drivers from peripheral or central nervous system,[99] altered laxity/stiffness of muscles,[100] laxity to injury of tendinous/ligamentous structures[101] to 'mal-adaptive' body mechanics.[99] Musculo-Skeletal Mechanics involved in gait and weightbearing activities can be mild to grossly impaired. PGP can begin peri or postpartum. There is pain, instability or dysfunction in the symphysis pubis and/or sacroiliac joints.
      • Postpartum depression
      • Postpartum psychosis
      • Round Ligament Pain. Pain experienced when the ligaments positioned under the uterus stretch and expand to support the woman's growing uterus
      • Thromboembolic disorders. The leading cause of death in pregnant women in the USA.[102]
      • Increased urinary frequency. A common complaint referred by the gravida, caused by increased intravascular volume, elevated GFR (glomerular filtration rate), and compression of the bladder by the expanding uterus.
      • Urinary tract infection[103]
      • Varicose veins. Common complaint caused by relaxation of the venous smooth muscle and increased intravascular pressure.
      • PUPPP skin disease that develop around the 32nd week. (Pruritic Urticarial Papules and Plaques of Pregnancy), red plaques, papules, itchiness around the belly button that spread all over the body except for the inside of hands and face.

      Ectopic pregnancy

      An ectopic pregnancy is a complication of pregnancy in which the embryo implants outside the uterine cavity.[104] With rare exceptions, ectopic pregnancies are not viable. Most ectopic pregnancies occur in the Fallopian tube (so-called tubal pregnancies), but implantation can also occur in the cervix, ovaries, and abdomen. It should be considered in any woman with abdominal pain or vaginal bleeding who has a positive pregnancy test. An ultrasound showing a gestational sac with fetal heart in a location other than the uterine cavity is clear evidence of an ectopic pregnancy. Tubal ectopic pregnancy is the most common cause of maternal death in the first trimester of pregnancy.[105]

      About 1% of pregnancies are in an ectopic location with implantation not occurring inside of the womb, and of these 98% occur in the Fallopian tubes.[105] In a typical ectopic pregnancy, the embryo adheres to the lining of the fallopian tube and burrows into the tubal lining. Most commonly this invades blood vessels which causes bleeding resulting in the expulsion of the implantation from the tube. Termed "tubal abortions", about half of ectopic pregnancies will resolve without treatment. The use of methotrexate treatment for ectopic pregnancy has reduced the need for surgery, but surgical intervention is still required in cases where the Fallopian tube has ruptured or is in danger of doing so. The surgical intervention may be laparoscopic or through a larger incision, known as a laparotomy.[106]

      A woman who has had a previous ectopic pregnancy is more likely to have another. The majority of women with ectopic pregnancies have had pelvic inflammatory disease or salpingitis, an inflammation of the fallopian tube. A history of gonorrhea or chlamydia can also cause tubal problems that increase the risk. Endometriosis, a condition that causes the tissue that normally lines the uterus to develop outside the uterus may slightly increase the incidence of an ectopic. The risk is increased in women who have unusually shaped fallopian tubes or tubes which has been damaged, possibly during surgery. Taking medication to stimulate ovulation increases the risk of ectopic pregnancy. Although pregnancy is rare when using birth control pills or an intrauterine device (IUD), if it does occur, it's more likely to be ectopic. Although pregnancy is rare after tubal ligation, if it does occur, it's more likely to be ectopic.[107] A recent meta-analysis of clinical outcomes has shown that cigarette smoking significantly increases the risk of tubal ectopic pregnancy.[105]

      Concomitant diseases

      In addition to complications of pregnancy that can arise, a woman may have other diseases or conditions (not directly caused by the pregnancy) that may become worse or be a potential risk to the pregnancy.

      Epidemiology

      In Europe, the average childbearing age has been rising continuously for some time. In Western, Northern, and Southern Europe, first-time mothers are on average 26 to 29 years old, up from 23 to 25 years at the start of the 1970s. In a number of European countries (Spain), the mean age of women at first childbirth has now even crossed the 30-year threshold.

      This process is not restricted to Europe. Asia, Japan and the United States are all seeing average age at first birth on the rise, and increasingly the process is spreading to countries in the developing world like China, Turkey and Iran. In the U.S., the age of first childbirth was 25 in 2006.[109]

      Society and culture

      In most cultures, pregnant women have a special status in society and receive particularly gentle care.[110] At the same time, they are subject to expectations that may exert great psychological pressure, such as having to produce a son and heir. In many traditional societies, pregnancy must be preceded by marriage, on pain of ostracism of mother and (illegitimate) child.

      Depictions of pregnant women can serve as mystically connotated symbols of fertility. The so-called Venus of Willendorf with its exaggerated female sexual characteristics (huge breasts and belly, prominent mons pubis) has been interpreted as indicative of a fertility cult in paleolithic Europe.

      Overall, pregnancy is accompanied by numerous customs that are often subject to ethnological research, often rooted in traditional medicine or religion. The baby shower is an example of a modern custom.

      Pregnancy is an important topic in sociology of the family. The prospective child is preliminarily placed into numerous social roles such as prospective heir or welfare recipient. (This may accelerate weddings.) The parents' relationship and the relation between parents and their surroundings are also affected.

      Arts

      Due to the important role of the Mother of God in Christianity, the Western visual arts have a long tradition of depictions of pregnancy.[111]

      Pregnancy, and especially pregnancy of unmarried women, is also an important motif in literature. Notable examples include Hardy's Tess of the d'Urbervilles and Goethe's Faust.

      Infertility

      Modern reproductive medicine offers a choice of measures for couples who stay childless against their will: fertility treatment, artificial insemination and surrogacy.

      Abortion

      An abortion is the termination of an embryo or fetus, either naturally or via medical methods. When done electively, it is more often done within the first trimester than the second, and rarely in the third.[54] Not using contraception, contraceptive failure, poor family planning or rape can lead to undesired pregnancies. Legality of socially indicated abortions varies widely both internationally and through time. In most countries of Western Europe, abortions during the first trimester were a criminal offense a few decades ago but have since been legalized, sometimes subject to mandatory consultations. In Germany, for example, as of 2009 less than 3% of abortions had a medical indication.

      Legal protection

      Many countries have various legal regulations in place to protect pregnant women and their children. Maternity Protection Convention ensures that pregnant women are exempt from activities such as night shifts or carrying heavy stocks. Maternity leave typically provides paid leave from work during roughly the last trimester of pregnancy and for some time after birth. Notable extreme cases include Norway (8 months with full pay) and the United States (no paid leave at all except in some states). Moreover, many countries have laws against pregnancy discrimination.

      References

      1. ^ "Embryo definition". MedicineNet, Inc. 27 April 2011. 
      2. ^ "Fetus definition". MedicineNet, Inc. 27 April 2011. 
      3. ^ "40% of pregnancies 'unplanned'". BBC News. 16 March 2004. 
      4. ^ Jayson, Sharon (20 May 2011). "Unplanned pregnancies in U.S. at 40 percent". PhysOrg.com. 
      5. ^ K. Joseph Hurt, Matthew W. Guile, Jessica L. Bienstock, Harold E. Fox, Edward E. Wallach (eds.). The Johns Hopkins manual of gynecology and obstetrics (4th ed.). Philadelphia: Wolters Kluwer Health / Lippincott Williams & Wilkins. p. 232. ISBN 9781605474335. 
      6. ^ "Trimester definition". MedicineNet, Inc. 27 April 2011. 
      7. ^ a b "definition of gravida". The Free Dictionary. Retrieved 17 January 2008. 
      8. ^ Robinson, Victor, Ph.C., M.D. (editor) (1939). "Primipara". The Modern Home Physician, A New Encyclopedia of Medical Knowledge. WM. H. Wise & Company (New York). , page 596.
      9. ^ "Definition of nulligravida". Merriam-Webster, Incorporated. Retrieved 9 March 2012. 
      10. ^ "Nulliparous definition". MedicineNet, Inc. 18 November 2000. 
      11. ^ "Fertilization". Retrieved 28 July 2010. 
      12. ^ a b Dr H. Kieler, O. Axelsson, S. Nilsson, U. Waldenströ (1995). "The length of human pregnancy as calculated by ultrasonographic measurement of the fetal biparietal diameter". Ultrasound in Obstetrics & Gynecology 6 (5): 353–357. doi:10.1046/j.1469-0705.1995.06050353.x. PMID 8590208. 
      13. ^ "Pregnancy Due Date Ranges". Spacefem.com. Retrieved 25 November 2011. 
      14. ^ "Definitions". Saskatchewan Prevention Institute. Retrieved 16 January 2008. 
      15. ^ Norwitz, MD, PhD, Errol R. "Postterm Pregnancy (Beyond the Basics)". UpToDate, Inc. Retrieved 24 August 2012. 
      16. ^ The American College of Obstetricians and Gynecologists (April 2006). "What To Expect After Your Due Date". Medem. Medem, Inc. Retrieved 16 January 2008. 
      17. ^ "Induction of labour – Evidence-based Clinical Guideline Number 9" (PDF). Royal College of Obstetricians and Gynaecologists. 2001. Archived from the original on 30 December 2006. Retrieved 18 January 2008. 
      18. ^ Stovall, M.D., Thomas G. (23 March 2004). "Postdate Pregnancy". Durham Obstetrics and Gynecology. Durham Obstetrics and Gynecology. Retrieved 18 January 2008. [dead link]
      19. ^ "Nonmedically Indicated Early-Term Deliveries". American College of Obstetricians and Gynecologists. 2013. Retrieved 24 March 2013. 
      20. ^ "Doctors To Pregnant Women: Wait At Least 39 Weeks". 18 July 2011. Retrieved 20 August 2011. 
      21. ^ "Definition of Premature birth". Medicine.net. Retrieved 16 January 2008. 
      22. ^ Lama Rimawi, MD (22 September 2006). "Premature Infant". Disease & Conditions Encyclopedia. Discovery Communications, LLC. Retrieved 16 January 2008. 
      23. ^ WHO | Early skin-to-skin contact for mothers and their healthy newborn infants
      24. ^ Jenkins, A; Millar, S; Robins, J (2011 Jul). "Denial of pregnancy: a literature review and discussion of ethical and legal issues.". Journal of the Royal Society of Medicine 104 (7): 286–91. PMID 21725094. 
      25. ^ Gabbe, Steven. Obstetrics : normal and problem pregnancies (6th ed. ed.). Philadelphia: Elsevier/Saunders. p. 1184. ISBN 9781437719352. 
      26. ^ "Pregnancy Symptoms". National Health Service (NHS). 11 March 2010. Retrieved 11 March 2010. 
      27. ^ a b "Early symptoms of pregnancy: What happens right away". Mayo Clinic. 22 February 2007. Retrieved 22 August 2007. 
      28. ^ a b "Pregnancy Symptoms – Early Signs of Pregnancy : American Pregnancy Association". Retrieved 16 January 2008. 
      29. ^ MedlinePlus > Breast pain Update Date: 31 December 2008. Updated by: David C. Dugdale, Susan Storck. Also reviewed by David Zieve.
      30. ^ "NHS Pregnancy Planner". National Health Service (NHS). 19 March 2010. Retrieved 19 March 2010. 
      31. ^ Qasim SM, Callan C, Choe JK (1996). "The predictive value of an initial serum beta human chorionic gonadotropin level for pregnancy outcome following in vitro fertilization". Journal of Assisted Reproduction and Genetics 13 (9): 705–8. doi:10.1007/BF02066422. PMID 8947817. 
      32. ^ "BestBets: Serum or Urine beta-hCG?". 
      33. ^ Verhaegen, J; Gallos, ID; van Mello, NM; Abdel-Aziz, M; Takwoingi, Y; Harb, H; Deeks, JJ; Mol, BW; Coomarasamy, A (2012 Sep 27). "Accuracy of single progesterone test to predict early pregnancy outcome in women with pain or bleeding: meta-analysis of cohort studies.". BMJ (Clinical research ed.) 345: e6077. PMID 23045257. 
      34. ^ Nguyen, T.H.; et al. (1999). "Evaluation of ultrasound-estimated date of delivery in 17 450 spontaneous singleton births: do we need to modify Naegele's rule?" (abstract). Ultrasound in Obstetrics and Gynecology 14 (1): 23–28. doi:10.1046/j.1469-0705.1999.14010023.x. PMID 10461334. Retrieved 18 August 2007. 
      35. ^ Whitworth, M; Bricker, L; Neilson, JP; Dowswell, T (2010 Apr 14). "Ultrasound for fetal assessment in early pregnancy.". Cochrane database of systematic reviews (Online) (4): CD007058. PMID 20393955. 
      36. ^ a b "Screening for Ultrasonography in Pregnancy". U.S. Preventive Services Task Force. Retrieved 6 March 2013. 
      37. ^ Bricker, L; Neilson, JP; Dowswell, T (2008 Oct 8). "Routine ultrasound in late pregnancy (after 24 weeks' gestation).". Cochrane database of systematic reviews (Online) (4): CD001451. PMID 18843617. 
      38. ^ Dimitrova V, Markov D, Dimitrov R (2007). "[3D and 4D ultrasonography in obstetrics]". Akush Ginekol (Sofiia) (in Bulgarian) 46 (2): 31–40. PMID 17469450. 
      39. ^ Sheiner E, Hackmon R, Shoham-Vardi I, et al. (2007). "A comparison between acoustic output indices in 2D and 3D/4D ultrasound in obstetrics". Ultrasound Obstet Gynecol 29 (3): 326–8. doi:10.1002/uog.3933. PMID 17265534. 
      40. ^ Rados C (January–February 2004). "FDA Cautions Against Ultrasound 'Keepsake' Images". FDA Consumer Magazine. Archived from the original on 13 May 2009. Retrieved 28 February 2012. 
      41. ^ Kempley R (9 August 2003). "The Grin Before They Bear It; Peek-a-Boo: Prenatal Portraits for the Ultrasound Set". Washington Post. 
      42. ^ trimester. CollinsDictionary.com. Collins English Dictionary – Complete & Unabridged 11th Edition. Retrieved 26 November 2012.
      43. ^ thefreedictionary.com > trimester Citing:
        • The American Heritage® Dictionary of the English Language, Fourth Edition, copyright 2000
      44. ^ Cunningham, et al., (2010). Williams Textbook of Obstetrics, chapter 8.
      45. ^ "Early pregnancy symptoms: Morning sickness, fatigue and other common symptoms". Retrieved 2011. 
      46. ^ "Pregnancy video". Channel 4. 2008. Retrieved 22 January 2009. 
      47. ^ a b "Pregnancy week by week". Retrieved 28 July 2010. 
      48. ^ "Pregnancy Week by week Symptoms". Retrieved 28 July 2010. 
      49. ^ Campbell, LA; Klocke, RA (2001 Apr). "Implications for the pregnant patient.". American journal of respiratory and critical care medicine 163 (5): 1051–4. PMID 11316633. 
      50. ^ "Starting labour". pregnancy-bliss.co.uk. Retrieved 14 January 2009. 
      51. ^ "Lightening During Pregnancy as an Early Sign of Labor". Giving Birth Naturally. Retrieved 22 August 2010. 
      52. ^ Stacey, T; Thompson, JM; Mitchell, EA; Ekeroma, AJ; Zuccollo, JM; McCowan, LM (2011 Jun 14). "Association between maternal sleep practices and risk of late stillbirth: a case-control study.". BMJ (Clinical research ed.) 342: d3403. PMID 21673002. 
      53. ^ Iams, JD; Romero, R; Culhane, JF; Goldenberg, RL (2008 Jan 12). "Primary, secondary, and tertiary interventions to reduce the morbidity and mortality of preterm birth.". Lancet 371 (9607): 164–75. PMID 18191687. 
      54. ^ a b Q&A: Miscarriage. (6 August 2002). BBC News. Retrieved 2007-04-22: "The risk of miscarriage lessens as the pregnancy progresses. It decreases dramatically after the 8th week."
        Lennart Nilsson, A Child is Born 91 (1990): at eight weeks, "the danger of a miscarriage … diminishes sharply."
        • "Women's Health Information", Hearthstone Communications Limited: "The risk of miscarriage decreases dramatically after the 8th week as the weeks go by." Retrieved 2007-04-22.
      55. ^ Kalverboer, edited by Alex F.; Gramsbergen, Albert (2001). Brain and behaviour in human development. Dordrecht: Kluwer. pp. 415–418. ISBN 9780792369431. 
      56. ^ Illes, ed. by Judy (2008). Neuroethics : defining the issues in theory, practice, and policy (Repr. ed.). Oxford: Oxford University Press. p. 142. ISBN 9780198567219. 
      57. ^ 3D Pregnancy (Image from gestational age of 6 weeks). Retrieved 2007-08-28. A rotatable 3D version of this photo is available here, and a sketch is available here.
      58. ^ 3D Pregnancy (Image from gestational age of 10 weeks). Retrieved 2007-08-28. A rotatable 3D version of this photo is available here, and a sketch is available here.
      59. ^ 3D Pregnancy (Image from gestational age of 20 weeks). Retrieved 2007-08-28. A rotatable 3D version of this photo is available here, and a sketch is available here.
      60. ^ 3D Pregnancy (Image from gestational age of 40 weeks). Retrieved 2007-08-28. A rotatable 3D version of this photo is available here, and a sketch is available here.
      61. ^ Lauersen, Niels H.; Stukane, Eileen (1998). The Complete Book of Breast Care (1st Trade Paperback ed.). New York: Fawcett Columbine/Ballantine. ISBN 978-0-449-91241-6. 
      62. ^ "Breast Sagging". Retrieved 2 February 2012. 
      63. ^ "Sagging Breasts". Channel 4. 2009. Retrieved 3 February 2012. 
      64. ^ Jay, Elizabeth (13 February 2009). "Will breastfeeding leave you with a little less lift?". Retrieved 2 February 2012. 
      65. ^ Thompson, Andrea (2 November 2007). "Breastfeeding Does Not Make Breasts Sag, Study Suggests". LiveScience.com. Retrieved 2 February 2012. 
      66. ^ Campolongo, Marianne (5 December 2007). "What Causes Sagging Breasts?". Retrieved 26 January 2012. 
      67. ^ Klusmann A, Heinrich B, Stöpler H, Gärtner J, Mayatepek E, Von Kries R (2005). "A decreasing rate of neural tube defects following the recommendations for periconceptional folic acid supplementation". Acta Paediatr. 94 (11): 1538–42. doi:10.1080/08035250500340396. PMID 16303691. Retrieved 20 January 2008. 
      68. ^ Stevenson RE, Allen WP, Pai GS, Best R, Seaver LH, Dean J, Thompson S (2000). "Decline in prevalence of neural tube defects in a high-risk region of the United States". Pediatrics 106 (4): 677–83. doi:10.1542/peds.106.4.677. PMID 11015508. 
      69. ^ Centers for Disease Control and Prevention (CDC) (2008). "Use of supplements containing folic acid among women of childbearing age—United States, 2007". MMWR Morb. Mortal. Wkly. Rep. 57 (1): 5–8. PMID 18185493. 
      70. ^ Salem N, Jr; Litman, B; Kim, HY; Gawrisch, K (2001 Sep). "Mechanisms of action of docosahexaenoic acid in the nervous system.". Lipids 36 (9): 945–59. PMID 11724467. 
      71. ^ Haider BA, Bhutta ZA (2006). "Multiple-micronutrient supplementation for women during pregnancy". In Bhutta, Zulfiqar A. Cochrane Database Syst Rev (4): CD004905. doi:10.1002/14651858.CD004905.pub2. PMID 17054223. 
      72. ^ Theobald HE (2007). "Eating for pregnancy and breast-feeding". J Fam Health Care 17 (2): 45–9. PMID 17476978. 
      73. ^ Basile LA, Taylor SN, Wagner CL, Quinones L, Hollis BW (2007). "Neonatal vitamin D status at birth at latitude 32 degrees 72': evidence of deficiency". J Perinatol 27 (9): 568–71. doi:10.1038/sj.jp.7211796. PMID 17625571. 
      74. ^ Kuoppala T, Tuimala R, Parviainen M, Koskinen T, Ala-Houhala M (1986). "Serum levels of vitamin D metabolites, calcium, phosphorus, magnesium and alkaline phosphatase in Finnish women throughout pregnancy and in cord serum at delivery". Hum Nutr Clin Nutr 40 (4): 287–93. PMID 3488981. 
      75. ^ Tarlow, MJ (1994 Aug). "Epidemiology of neonatal infections.". The Journal of antimicrobial chemotherapy. 34 Suppl A: 43–52. PMID 7844073. 
      76. ^ "Weight Gain During Pregnancy: Reexaminging the Guidelines, Report Brief". Institute of Medicine. Retrieved 29 July 2010. 
      77. ^ American College of Obstetricians and Gynecologists (January 2013). "Weight Gain During Pregnancy". Obstet Gynecol 121: 210–2. 
      78. ^ "Pregnancy and Exercise: Baby Let's Move!". Mayo Clinic. Retrieved 29 July 2010. 
      79. ^ WADSWORTH, P (1 May 2007). "The Benefits of Exercise in Pregnancy". The Journal for Nurse Practitioners 3 (5): 333–339. doi:10.1016/j.nurpra.2007.03.002. 
      80. ^ Shaji, Reena (13 January 2009). "Drugs in pregnancy and teratogenicity". LifeHugger. 
      81. ^ "99% of pregnant women in US test positive for multiple chemicals including banned ones, study suggests". Sciencedaily.com. 14 January 2011. doi:10.1289/ehp.1002727. Retrieved 25 November 2011. 
      82. ^ Ornoy, A; Ergaz, Z (2010 Feb). "Alcohol abuse in pregnant women: effects on the fetus and newborn, mode of action and maternal treatment.". International journal of environmental research and public health 7 (2): 364–79. PMID 20616979. 
      83. ^ Hackshaw, A; Rodeck, C; Boniface, S (2011 Sep-Oct). "Maternal smoking in pregnancy and birth defects: a systematic review based on 173 687 malformed cases and 11.7 million controls.". Human reproduction update 17 (5): 589–604. PMID 21747128. 
      84. ^ Irner, TB (2012). "Substance exposure in utero and developmental consequences in adolescence: a systematic review.". Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence 18 (6): 521–49. PMID 22114955. 
      85. ^ a b Abelsohn, A; Vanderlinden, LD; Scott, F; Archbold, JA; Brown, TL (2011 Jan). "Healthy fish consumption and reduced mercury exposure: counseling women in their reproductive years.". Canadian family physician Medecin de famille canadien 57 (1): 26–30. PMID 21322285. 
      86. ^ Backes, CH; Nelin, T; Gorr, MW; Wold, LE (2013 Jan 10). "Early life exposure to air pollution: how bad is it?". Toxicology letters 216 (1): 47–53. PMID 23164674. 
      87. ^ "Chapter 1, Lead-based Paint Hazards, 98–112". Cdc.gov. Retrieved 25 November 2011. 
      88. ^ Sex during pregnancy: What's OK, what's not - MayoClinic.com
      89. ^ M.P. Bermudez; A.I. Sanchez, G. Buela-Casal (2001). "Influence of the Gestation Period on Sexual Desire". Psychology in Spain 5 (1): 14–16. 
      90. ^ Wing Yee Fok; Louis Yik-Si Chan, Pong Mo Yuen (October 2005). "Sexual behavior and activity in Chinese pregnant women". Acta Obstetricia et Gynecologica Scandinavica 84 (10): 934–938. doi:10.1111/j.0001-6349.2005.00743.x. PMID 16167907. 
      91. ^ Reamy K; White SE, Daniell WC, Le Vine ES (June 1982). "Sexuality and pregnancy. A prospective study". J Reprod Med. 27 (6): 321–7. PMID 7120209. 
      92. ^ Malarewicz A, Szymkiewicz J, Rogala J (September 2006). "[Sexuality of pregnant women]". Ginekol. Pol. (in Polish) 77 (9): 733–9. PMID 17219804. 
      93. ^ Cory Silverberg (19 September 2011). "Pregnancy Sex Positions: ideas for comfortable sex positions during pregnancy". About.com Guide. 
      94. ^ Kramer, MS; McDonald, SW (19 July 2006). "Aerobic exercise for women during pregnancy". In Kramer, Michael S. Cochrane database of systematic reviews (Online) 3 (3): CD000180. doi:10.1002/14651858.CD000180.pub2. PMID 16855953. 
      95. ^ a b Artal, R; O'Toole, M (2003 Feb). "Guidelines of the American College of Obstetricians and Gynecologists for exercise during pregnancy and the postpartum period.". British journal of sports medicine 37 (1): 6–12; discussion 12. PMID 12547738. 
      96. ^ "Reproductive Health and Research Publications: Making Pregnancy Safer". World Health Organization Regional Office for South-East Asia. 2009. Retrieved 7 December 2009. 
      97. ^ Merck. "Pregnancy complicated by disease". Merck Manual, Home Health Handbook. Merck Sharp & Dohme. 
      98. ^ Mondelli,M.; Rossi,S.; Monti,E.; Aprile,I.; Caliandro,P.; Pazzaglia,C.; Romano,C.; Padua,L. (2007) Long term follow-up of carpal tunnel syndrome during pregnancy: a cohort study and review of the literature. Electromyogr Clin Neurophysiol. 2007 Sep;47(6):259–71.
      99. ^ a b O'Sullivan, Peter B.; Beales, Darren J. (May 2007). "Diagnosis and classification of pelvic girdle pain disorders—Part 1: A mechanism based approach within a biopsychosocial framework". Manual Therapy 12 (2): 86–97. doi:10.1016/j.math.2007.02.001. PMID 17449432. 
      100. ^ European guidelines for the diagnosis and treatment of pelvic girdle pain.Eur Spine J. 2008 Feb 8 Vleeming A, Albert HB, Ostgaard HC, Sturesson B, Stuge B.
      101. ^ Possible role of the long dorsal sacroiliac ligament in women with peripartum pelvic pain. Acta Obstetricia et Gynecologica Scandinavica Volume 81 Issue 5 Page 430-436, May 2002, Andry Vleeming, Haitze J. de Vries, Jan M. A Mens, Jan-Paul van Wingerden
      102. ^ C. Blackwell, Sean (December 2008). "Thromboembolic Disorders During Pregnancy". Merck Sharp & Dohme Corp. 
      103. ^ Merck. "Urinary tract infections during pregnancy". Merck Manual Home Health Handbook. 
      104. ^ Page EW, Villee CA, Villee DB. Human Reproduction, 2nd Edition. W. B. Saunders, Philadelphia, 1976. p. 211. ISBN 0-7216-7042-3. 
      105. ^ a b c Shaw, J. L. V.; Dey, S. K., Critchley, H. O. D., Horne, A. W. (January 2010). "Current knowledge of the aetiology of human tubal ectopic pregnancy". Human Reproduction Update 16 (4): 432–444. doi:10.1093/humupd/dmp057. PMC 2880914. PMID 20071358. 
      106. ^ Laparoscopic Ectopic Pregnancy Surgery - Powered by World Laparoscopy Hospital
      107. ^ Ectopic pregnancy: Risk factors - MayoClinic.com
      108. ^ a b Health Care Guideline: Routine Prenatal Care. Fourteenth Edition. By the Institute for Clinical Systems Improvement. July 2010.
      109. ^ T.J., Mathews; Brady E. Hamilton (August 2009). "Delayed childbearing: More women are having their first child later in life". NCHS Data Brief (National Center for Health Statistics) (25). ISSN 1941-4927. 
      110. ^ Womack, Mari (2010). The anthropology of health and healing.. Plymouth: AltaMira Press. p. 133. ISBN 978-0-7591-1044-1. 
      111. ^ Rossi, Timothy Verdon ; captions by Filippo (2005). Mary in western art. New York: In Association with Hudson Hills Press. p. 106. ISBN 0-9712981-9-X. 

      External links

      source: http://en.wikipedia.org/wiki/Pregnancy
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